Dotmatics

This presentation introduces Dotmatics Luma, an AI-native platform designed to accelerate antibody discovery and development. The speaker discusses how Luma addresses the challenge of fragmented data across research organizations by providing a connected ecosystem that integrates design, process, and results. The platform features BioGlyph, a visual design tool that uses building blocks to create composable antibody formats, enabling rapid iteration and collaboration. Key capabilities include tracking scientific relationships and lineages, integrating experimental data with design data, and leveraging Agent Luma for AI-powered data interrogation. The presentation covers a hypothetical Alzheimer's treatment scenario using anti-transferrin antibodies to deliver therapeutic enzymes across the blood-brain barrier. Future enhancements include format rescue functionality for annotating legacy sequences and early-phase analysis integration. The platform aims to enable 'lab in the loop' workflows that accelerate the journey from scientific ideas to innovation through better collaboration, resource planning, and data-driven decision making.

This webinar provides an overview of Affinity Selection Mass Spectrometry (ASMS), a binding assay technique for identifying noncovalent compound binders to target proteins. The presentation covers the fundamentals of ASMS workflow, which involves mixing target proteins with compound libraries, using two-dimensional LC-MS separation, and identifying hits through mass spectrometry. The speaker discusses the benefits and limitations of ASMS, including its label-free nature and flexibility, as well as challenges with data analysis when dealing with hundreds of compounds in single wells. The main focus is on Versidian's improvements to their Analytical Studio software, particularly workflow automation enhancements that streamline sample list generation, data transfer, and initial processing. Key improvements include automated cross-hit filtering that eliminates false positives 70-80% faster than previous versions, and new KD analysis capabilities for dose-response curve analysis. The presentation demonstrates how the automated workflow reduces manual steps while maintaining accuracy in hit identification and confirmation.